Uropathogenic E.coli induces DNA damage in the bladder
As provider of the whole genome sequencing, IntegraGen is proud of sharing this new publication.
Urinary tract infections (UTIs) are caused by an uropathogenic strain of Escherichia coli that produce colibactin, a bacterial genotoxin.
In the study led by the Institut de Recherche en Santé Digestive IRSD team from the University of Toulouse, researchers observed extensive DNA damages in bladder progenitor cells of rodent UTI model caused by the genotoxic activity of colibactin production.
These results suggest the implication of UTIs in the development of bladder cancer, opening new perspectives for future investigation.