Clinical Grade Sequencing
Incorporating genome-wide sequencing into an oncology clinical research program necessitates expertise in operating the latest sequencing technologies and the ability to obtain and manage accurate data. Since there is a critical time frame for obtaining a tumor sample and processing sequencing data in order to support the clinical decision-making process, the challenge for institutions is to establish a reproducible process that permits routine exome and transcriptome sequencing in a timely manner. Critical needs include:
- Rapid turnaround time from receipt of the samples to sequence full analysis
- Easy and secure access to analyzed data allowing rapid review by biologists and clinicians
Our Experience
IntegraGen has worked with leading academic institutions to set up high-throughput sequencing platforms. We have operated Gustave Roussy’s platform, the largest cancer center in Europe, since 2014 delivering timely exome and RNA sequencing data in support of the center’s oncology clinical research program.
We also have the know-how and experience to establish operational processes that increase the flexibility of your sequencing platform while also optimizing the operational costs.
Pharmacogenomics
Pharmacogenomics is the study of how genes can affect an individual’s response to pharmaceutical therapies. Research in this area combines pharmacology and genetics to aid in the personalization of drug therapy by identifying genetic markers which can determine an individual’s likelihood of responding to a drug, the need for individualized drug dosing, or the risk of side effects.
Examples of services IntegraGen offers which support pharmacogenomic research projects include:
Sequencing
- Whole exome sequencing
- Genes panels
Expression
- Expression profiles
- RNA-SEQ
- Small RNA-SEQ
Genotyping
- ADME SNPs panels
- GWAS
