Uropathogenic E.coli induces DNA damage in the bladder

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Background

Urinary tract infections (UTIs) are caused by an uropathogenic strain of Escherichia coli that produce colibactin, a bacterial genotoxin.

Results

In the study led by the Institut de Recherche en Santé Digestive IRSD team from the University of Toulouse, researchers observed extensive DNA damages in bladder progenitor cells of rodent UTI model caused by the genotoxic activity of colibactin production.

Conclusion

These results suggest the implication of UTIs in the development of bladder cancer, opening new perspectives for future investigation.